Childhood-onset versus adult-onset Sjögren Syndrome: Clinical phenotype, disease activity, and predictors of organ damage in a national multicenter cohort

Kilic Konte E; Sahin S; Firat Sentürk E; Yekedüz Bülbül A; Arslanoglu C; Orhan Erkan M; Kücükali B; Ugur Es Y; Kara Canlioglu N; Koker O; Kilbas G; Oguz G; Sahin C; Selim Kul M; Miray Kisla Ekinci R; Sümer G; Anıl Akın O; Ilgaz Tüzen H; Bozkaya Yücel B; Kisaoglu H; Emine Sonmez H; Ozen Balci M; Isgüder R; Sener S; Demirkan FG; Can Eroglu E; Kacmaz HM; Cakmak F; Haslak F; Türkucar S; Celikel E; Gezgin Yildirim D; Demir S; Sag E; Basaran O; Kasap Demir B; Kilic SS; Kalyoncu M; Balat A; Aktay Ayaz N; Pac Kisaarslan A; Sozeri B; Yüksel S; Ugurlu S; Kasapcopur O

doi:10.1016/j.semarthrit.2026.153060

COHORT · low certainty

Childhood-onset versus adult-onset Sjögren Syndrome: Clinical phenotype, disease activity, and predictors of organ damage in a national multicenter cohort

Kilic Konte E et al. · Seminars in arthritis and rheumatism · Tuesday, August 18, 2026

In this retrospective cohort, childhood-onset Sjögren was associated with higher organ damage risk; not yet practice-changing without prospective validation.

Design Cohortn 197Funding Not reported

The finding: No significant difference was found.

Why it matters: First national multicenter cohort comparing childhood versus adult disease phenotypes; identifies age-of-onset as a predictor of organ involvement.
Limitations: Retrospective cohort design; no comparator arm; cross-sectional analysis limits causal inference.

Source

Kilic Konte E et al.. Childhood-onset versus adult-onset Sjögren Syndrome: Clinical phenotype, disease activity, and predictors of organ damage in a national multicenter cohort. Seminars in arthritis and rheumatism. Tuesday, August 18, 2026.
doi:10.1016/j.semarthrit.2026.153060Read original ↗

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Automated evidence summary, checked against the source. Not medical advice. Verify with the original publication.