COHORT · low certainty
Anatomical-Functional Dissociation in Diabetic Macular Edema: Five-Year Outcomes of Treat-and-Extend Versus Pro Re Nata Anti-VEGF Regimens
In this retrospective cohort, treat-and-extend was associated with greater central subfield thickness reduction; not yet practice-changing.
Design CohortFunding Not reported
- The finding
- No significant difference was found.
- Why it matters
- First five-year outcomes comparing treat-and-extend to pro re nata in diabetic macular edema; cohort study with low certainty.
- Limitations
- Retrospective cohort study; low certainty due to potential biases.
Statistics · confidence intervals & p-values
BCVA change at five years (T&E vs PRN) vs PRN regimen: MD −0.7 (95% CI −2.4–1) p<0.05
Effect by outcomeMD· 95% CI
BCVA change at five years (T&E vs PRN)vs PRN regimen
-0.7[-2.4, 1]
Source
Başkan B et al.. Anatomical-Functional Dissociation in Diabetic Macular Edema: Five-Year Outcomes of Treat-and-Extend Versus Pro Re Nata Anti-VEGF Regimens. Journal of clinical medicine. Thursday, August 20, 2026.
doi:10.3390/jcm15166450Read original ↗
doi:10.3390/jcm15166450Read original ↗
Generated, then checked against the source · how this brief was built →
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Automated evidence summary, checked against the source. Not medical advice. Verify with the original publication.